The study of climate changes is most often based on the analysis of time series of temperature and precipitation in urban areas and the increase in the emission of gases having a greenhouse effect. On the other hand, the selection of representative and relevant stations and comprehensive analysis of climate indicators lead to better and more exact assessments on climate changes at the regional level. In order to connect climate changes with agricultural, biological, socio-economic, and tourism databases, the paper deals with the dynamic analysis of changes in thermal component expressed through the values of regional climate indices in four climatological stations with different geographical positions in Serbia. There are significant differences between the two time series data (1961-1990 and 1991-2013) on temperature and humidity, precipitation, insolation, and wind speed. However, after using the climatic indices as a tool for assessing climate changes, the results of the study suggest the relative influence of the thermal component on the change of climate indices, with a slight increase in the index of significance for human activities. Relying on the results of this alternative approach to the study of climate changes, the fact remains that the climate is not fixed but highly variable factor that should be taken into consideration in terms of monitoring, evaluation, and management of the area
