There is an increasing interest for the 99mTc labeling of biomolecules by using
bifunctional chelating agents like ethylenediamine-N,N´-di-3-propanoate diethyl
ester (deeddp). To find new ligand, which can be linked to the small biomolecules
and coordinated with [99mTc(CO)3(H2O)3]
+
precursor, is a challenging task.
Radiolabeling of deeddp with [99mTc(CO)3(H2O)3]
+
precursor, stability studies and
biodistribution of formed complexes were carried out, including challenge with
histidine. Radiochemical yield of 99mTc(I)-tricarbonyl-deeddp complexes was
higher than 95%. These complexes were stable in vitro and showed a very good
biological behavior. The radiochemical and biological features of the novel
99mTc(I)-complexes, as well as, the nature of the ligands, make them very
promising candidates for labeling of tumor specific biomolecules.Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 24-28 September 201