Novel diamine-dioxime ligand, 4,7-diaza-3,8-diethyldecane-2,9-dione bis oxime
(LH2), derivative of hexamethyl-propylene amine oxime (HMPAO), was
synthesized in order to develop new brain perfusion imaging agent, based on
99mTc(V) complexes. The 99mTc(V)-d,l-HMPAO complex is well-known
radiopharmaceutical for brain imaging. The structures of the synthesized
compound were characterized by UV-Vis, IR, 1
H NMR and 13C NMR. The
procedure for radiolabeling of diamine-dioxime with 99mTc was developed and
radiolabeling yield of the 99mTc-complex was followed by paper and thin-layer
chromatography. The maximum radiolabeling yield was obtained when the
reactions were carried out at pH~9 within 10 min at room temperature (RT).
Biodistribution studies on rats has shown significant uptake of 99mTc-complex
(2.1% ID), 2 min after injection.Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 24-28 September 201
