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An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations
Authors
Rebecca A. Butcher
Jon Clardy
Justin R. Ragains
Publication date
16 July 2009
Publisher
LSU Digital Commons
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Abstract
In Caenorhabdltls elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, nonaging dauer larval stage. Here, using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer formation at higher concentrations. © 2009 American Chemical Society
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Last time updated on 26/10/2023