Agbadua Orinamhe Godwin

Gáti Tamás

Hunyadi Attila

Kúsz Norbert

Tóth Gábor

English

University of Szeged

Fiatal Gyógynövénykutatók Fóruma Budapest, 2022. június 17.  18 A10 DOI: 10.14232/fgykf.2022.a10  Biomimetic oxidized resveratrol metabolite mixtures  Orinamhe Godwin Agbadua1, Norbert Kúsz1, Tamás Gáti2, Gábor Tóth3, Attila Hunyadi1  1 Institute of Pharmacognosy, University of Szeged, Szeged, Hungary 2 Servier Research Institute of Medicinal Chemistry (SRIMC), Budapest, Hungary 3 NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Tech-nology and Economics, Budapest, Hungary  There is an increasing interest in the chemical space of the metabolites that may be formed from an antioxidant upon scavenging reactive oxygen or nitrogen species (ROS/RNS) [1]. Resveratrol, a well-known natural plant polyphenol with a plethora of pharmacological activities most nota-bly its antioxidant properties [2], can efficiently scavenge various types of ROS/RNS, resulting in several radical intermediates whose chemical stabilization may lead to various bioactive com-pounds [3]. Our current studies aimed at evaluating some potential pharmacological implications of resvera-trol oxidation. Oxidation through various chemical reactions, including biomimetic approaches, resulted in several mixtures that exhibited greater bioactivities compared to the parent com-pound. Mixtures were tested for their in vitro antioxidant activities (DPPH, ORAC), and inhibitory action on cyclooxygenase 1 and 2, lipoxygenase, xanthine oxidase, and angiotensin converting enzyme.  Using a multi-step chromatographic isolation procedure and spectral analysis, a diverse group of compounds including dimers, chlorine-, iodine-, ethoxy- and benzofuran derivatives were ob-tained in pure form. Evidently, the final oxidation products and the stability of the intermediate species resulting from the oxidative reactions vary depending on the surroundings as well as the nature of oxidative process. While all groups of metabolites showed enhanced activity in inhibiting angiotensin converting enzyme, the dimers exhibited the greatest inhibitory activity on lipoxygenase enzyme, with chlo-rine- and iodine-substituted compounds exhibiting greatest antioxidant activities and xanthine oxidase inhibition.   [1] Hunyadi A, Med. Res. Rev. (2019) 1-29; [2] Springer M, Moco S. Nutrients (2019), 11, 143; [3] Shingai et al., J. Agric. Food Chem. (2011), 569, 8180-8186  This work was supported by the National Research, Development and Innovation Office, Hun-gary (NKFIH; K-134704). I would also like to acknowledge the Stipendium Hungaricum Scholar-ship.  Supervisor: Attila Hunyadi  

Biomimetic oxidized resveratrol metabolite mixtures

http://acta.bibl.u-szeged.hu/76045/1/fiatal_gyogynovenykutatok_foruma_2022_018.pdf

Biomimetic oxidized resveratrol metabolite mixtures

Abstract

Similar works

Full text

Available Versions

University of Szeged