Gáborová Mária

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University of Szeged

3rd Symposium of  Young Researchers on  Pharmacognosy    Szeged, 3–4 February 2022  BOOK OF ABSTRACTS     3rd Symposium of Young Researchers on Pharmacognosy  BOOK OF ABSTRACTS (ed. Tivadar Kiss, Judit Hohmann) Department of Pharmacognosy, University of Szeged, Szeged, Hungary  3–4 February 2022      doi: 10.14232/syrpharmacognosy.2022.af   3rd Symposium of Young Researchers on Pharmacognosy  11 A6 doi: 10.14232/syrpharmacognosy.2022.a6  Isolation and identification of diterpenes  of the genus Plectranthus sensu lato  Mária Gáborová  Email: maria.gborov@gmail.com  The genus Plectranthus sensu lato (Lamiaceae), which according to the latest systematic revision includes three separate genera (Coleus, Plectranthus sensu stricto and Equilabium), is well-known due to its medicinal properties. Many species have been used in the treatment of various ailments of gastrointestinal, genitourinary, respiratory tract and skin for centuries [1,2]. Phytochemical studies have revealed that the genus Plectranthus s.l. is a rich source of phenolic compounds and terpenes. Within the group of terpenoids, diterpenes have become the most studied group because of their significant structural diversity and promising biological activities such as antimicrobial, antiprotozoal, cardiotonic, hypotensive, gastroprotective, and cytotoxic activity [2,3]. Our investigation of the methanolic extracts of the aerial parts of P. ciliatus, C. forsteri 'Marginatus', and C. comosus led to the isolation of six abietane diterpenes and two kaurane diterpenes. Two of them were isolated from a natural source for the first time. The compounds were obtained using different chromatographic methods such as column chromatography, flash chromatography, and RP-HPLC and their structures were elucidated by high-resolution mass spectrometry and 1D and 2D NMR spectroscopy.  Supervisors: Renata Kubínová, Attila Hunyadi, Máté Vágvölgyi  References [1] Paton AJ et al. PhytoKeys 2019; 129:1–158. [2] Lukhoba CW et al. Journal of Ethnopharmacology 2006; 103:1–24. [3] Gáborová M et al. Molecules 2022; 27:166.   

Isolation and identification of diterpenes of the genus Plectranthus sensu lato

http://acta.bibl.u-szeged.hu/74193/1/syrpharmacognosy_2022_011.pdf

Isolation and identification of diterpenes of the genus Plectranthus sensu lato

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