In this work authors have evaluated the positive predictive value of 16-multidetector-row CT angiography (CTA) in comparison with conventional invasive angiography (CIA) in the diagnosis of significant stenosis. For this purpose, 8 patients suspected to significant stenosis was investigated. These patients were undertaken CIA procedure after CTA. Result of this study reveals that for patient-base analysis, the positive predictive value of CTA was 87.5. The findings of this study reveal that CT angiography with 16-slice scanner might be considered as an acceptable technique for rapid triage of patients. High values of PPV reveal a moderate performance of CTA. However, due to low number of patients,the obtained results cannot be used for final decision