Climate change is the biggest global health threat of the 21st century. Climate change is adversely affecting the human health. Maximum impact of global warming and climate change will be seen on underdeveloped and developing countries like India. In Indian context the implications of climate change are broadly classified into rising sea levels, increasing CO2 levels, rising temperatures and extreme weather conditions. Climate change affects the human health in various ways. In developing countries like India, the health sector and the infrastructural facilities are very weak. The impact of the human activity on climate system is the most serious environmental challenge nowadays. The impacts of climate change on human health will be difficult to reverse in a few years or decades. Yet, these possible impacts can be avoided or controlled. This paper analyses the challenges of climate change on health