ASAKUMA,  Mitsuhiro

HIROKAWA, Fumitoshi

KAGOTA, Shuji

KOMEDA, Koji

LEE,  Sang-Woong

SHIMIZU, Tetsunosuke

TANIGUCHI, Kohei

TOMIOKA, Atsushi

UCHIYAMA, Kazuhisa

Pancreatic cancer is a leading cause of cancer-related deaths. Although advances in chemotherapy and radiotherapy have improved patient outcomes, pancreatic cancer remains a refractory disease. Herein, we describe a patient with 
pancreatic cancer who underwent an effective multidisciplinary treatment comprising heavy particle radiotherapy and 
hyperthermia. A 64-year-old woman underwent distal pancreatectomy for pancreatic cancer; however, a single liver 
metastasis was discovered 12 months after surgery. Heavy particle radiotherapy and oral tegafur/gimeracil/oteracil 
were administered to treat the metastasis. Thereafter, the patient underwent laparoscopic lateral segmentectomy of the 
liver. However, 12 months after hepatectomy, peritoneal dissemination with elevated serum carbohydrate antigen 19-9 levels was detected. The patient received combination therapy with gemcitabine and nanoparticle albumin-bound 
paclitaxel and subsequently underwent hyperthermia therapy with low-dose S-1 administration. While serum carbohydrate antigen 19-9 levels decreased more than expected over the first 9 months of hyperthermia therapy, the patient 
died the following month. Overall, the patient survived for 4 years after liver metastasis was detected and 3 years 
post-peritoneal dissemination. In an era where novel therapeutic strategies are required for treating aggressive malignancies, our report illustrates the potential effectiveness of multidisciplinary treatments in patients with unresectable 
pancreatic canc

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Multidisciplinary Treatment Comprising Heavy Particle Radiotherapy  and Hyperthermia is Effective Against Liver Metastasis Arising from  Pancreatic Cancer: A Case Report

Multidisciplinary Treatment Comprising Heavy Particle Radiotherapy and Hyperthermia is Effective Against Liver Metastasis Arising from Pancreatic Cancer: A Case Report

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