FUJIKI, Youhei

HATA, Kenichiro

ISHIDA, Takaaki

KOTANI, Takuya

MAKINO, Shigeki

MATSUDA, Shogo

SUZUKA, Takayasu

TAKEUCHI, Tohru

Objective: To explore short- and long-term prognosis and its related factors in polymyositis/dermatomyositis (PM/
DM) with acute/subacute interstitial pneumonia (A/SIP).
Methods: Subjects were 59 patients with PM/DM-A/SIP (38 survivors and 21 deaths). Data are expressed as the 
median (interquartile range).
Results: The median age of patients was 63.0 years. The cause of death in 12, 5, and 3 patients were respiratory 
failure due to IP, infectious diseases, and malignancies, respectively. As infectious diseases, 2 patients died of sepsis, 
and 3 patients died of cytomegalovirus infection, bacterial pneumonia, and suspected viral encephalitis, respectively. 
Survival periods from onset to death were 6.6 (5.7 – 14.0) weeks in IP, 25.2 (23.6 – 214.4) weeks in infectious disease, 
and 187.6 (133.4 – 206.6) weeks in malignancies. In the dead patients with IP, the positive rate of anti-melanoma 
differentiation-associated gene 5 antibody (p = 0.001), the levels of serum ferritin (p = 0.017), and values of P[A-a]O2
(p < 0.001) were significantly higher than those in the survivors, whereas the levels of serum albumin (p = 0.008) were 
significantly lower.
Conclusion: The most frequent cause of death in patients with PM/DM-A/SIP were respiratory failure due to IP, 
followed by infection and malignancy. The results showed that hypoalbuminemia was associated with poor prognosis

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Short- and Long-Term Prognosis of Polymyositis/Dermatomyositis with Acute/Subacute Interstitial Pneumonia: A Retrospective Study

Short- and Long-Term Prognosis of Polymyositis/Dermatomyositis with Acute/Subacute Interstitial Pneumonia: A Retrospective Study

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