This research study about novel entitled “No Longer Human” using theory of Nihilism by Friedrich Nietzsche. This study aims to 1) describe characterization of Oba Yozo, 2) reveal the idea of nihilism as reflected in Oba Yozo, and 3) find the destructive effect of nihilism in Oba Yozo’s life. This research is qualitative research. The data is collected by note-taking and the technique of analyzing data is using 3 stages of data analyze by Miles & Huberman called data reduction, data display, and conclusion drawing. To determine the accuracy of this research, the theory triangulation is used as data validity. The researcher finds the characterization of Oba Yozo through Murphy’s method of analyzing character. The nihilism idea such as insecurity, lack of gaining composure, ashamed of oneself, negate all meaning in life, and believe in nothings is occurred in Oba Yozo’s life which caused some destructive effect includes alcohol and drugs addict, prostitution, and suicidal attempt
