Obesity negatively affects the pathological states of chronic inflammation, such as Psoriasis and
Psoriatic Arthritis. The inflammatory cytokines released by the adipose tissue determine, in addition to
inflammation, a condition of insulin resistance, which is also a comorbidity of psoriasis. The state of
chronic inflammation unites both psoriasis and obesity. The first is an autoimmune skin disease, where
very thick skin layers are evident due to an abnormal proliferation of keratinocytes; obesity, on the
other hand, represents one of the possible comorbidities of psoriasis the simultaneous presence in the
same subject of two or more diseases
