Local agri-food products are conceived as a form of cultural capital, representing potentially fruitful resources for rural development. Italy and its regions offer a rich and diverse agricultural and food heritage that has led to the creation of numerous quality agri-food systems. Despite their ability to absorb disturbances and maintain their functions, it is important to develop economic models targeted to analyse the relationships among the components of food systems, in order to identify their strengths and weaknesses and drive the implementation of sectoral policies. In view of the new Rural Development Programme (2014-2020), the aim of this work is to analyse the structure of the Basilicata’s agri-food system using a multi-sector model based on a two-region SAM, specifically developed for Basilicata, an Italian region charac-terised by a highly specialised agri-food sector. Results show that the availability of a highly disaggregate multi-sector model of the regional economy may be a valuable supporting tool to design regional policies for innovation and for the development of rural areas, laying the foundation for further analysis