中文摘要 背景：钙化性主动脉瓣病（calcificaorticvalvedisease，CAVD）在发达国家已经成为第三大常见心血管疾病，目前无特效的药物治疗，外科手术和介入置换是最有效的治疗方式。糖基化终末产物（advancedglycationendproducts，AGEs）是非酶糖基化反应(Mailland反应)的终末产物，西方国家高脂饮食的生活方式可以导致体内产生大量糖基化终末产物。AGEs可以引起很多种病理过程，其中就包括动脉粥样硬化。有报道称动脉粥样硬化和CAVD具有相似的病理过程和危险因素。内皮间质转化（EndothelialtoMesenchymalTransition，E...Abstract Background Calcific aortic valvar disease (CAVD) has been the third most common cardiovascular disease in the developed countries, causing significant morbidity and mortality. Currently, there is no effective drug therapy, but surgical and interventional treatments are the only effective therapeutic methods. It has already been reported that CAVD and atherosclerosis share similar pathol...学位：医学硕士院系专业：医学院_外科学学号：2452014115353
