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A Preliminary Study On Activating AMPK By MED

Abstract

依赖于5’-AMP激活的蛋白激酶——AMPK在保持细胞微环境的能量稳态上扮演了至关重要的角色,能够被细胞内AMP的增多和ATP的减少所激活,作为代谢感受器调节细胞内ATP相关的代谢途径。AMPK除了调节糖代谢,脂代谢,蛋白质合成等很多能量相关的物质代谢途径外,还在细胞凋亡和血管生成途径中起到重要调节作用。如果能量代谢失衡,则会引起代谢综合症等多种疾病,严重影响现代人的生活,威胁人的健康。作为能量代谢过程中的关键酶,AMPK可以作为代谢综合症的治疗靶点。 AMPK不仅能够被细胞内AMP/ATP的比值上升所激活,也能够被其细胞内的上游激酶所调控,还会响应于缺氧、缺血、氮氧化合物等细胞胁迫作用而激...AMP-activated protein kinase plays an important role in keeping a cellular energy homeostasis, which is activated in response to the increasing of intracellular AMP or the decreasing of intracellular ATP, modulating ATP-related metabolism pathway. Besides glucose metabolisam, lipid metabolism,and synthesis of protein, AMPK is also very important in cell apoptosis and vein generation. Metabolic Syn...学位:理学硕士院系专业:生命科学学院_微生物学学号:2162007115201

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