背景：角膜（cornea）是眼睛前端的一层透明组织，角膜上皮（cornealepithelium）位于角膜的最外层，传统观点上认为角膜上皮的自我更新能力主要依赖于角膜缘干细胞，角膜缘干细胞缺乏（limbalstemcelldeficiency，LSCD）可导致角膜混浊、结膜化、血管化和视力下降。多种因素可导致角膜缘干细胞缺乏，但目前角膜缘干细胞缺乏的发病机制尚未明确。脂类代谢（lipidmetabolism）是机体的重要的三大代谢之一，过氧化物酶体增殖物激活受体alpha（peroxisomeproliferators-activatedreceptoralpha，PPARα）在脂代谢中发挥着...Background： Corneal epithelium is located at the outermost layer of cornea, a transparent tissue in front of the eye. The traditional view believes that cornea epithelia are renewed constantly by the adult stem cells which are located in the limbus. Limbal stem cell deficiency（LSCD）is clinically characterized by a classic triad of signs, including corneal opacity, conjunctivalization, neovascular...学位：理学博士院系专业：医学院_生理学学号：2452013015432
