蜕皮激素在节肢动物蜕皮、附肢再生以及繁殖等生理过程起着重要作用。蜕皮激素受体(Ecdysonereceptor,EcR)在整个蜕皮激素信号通路中起重要作用。当蜕皮激素合成达到一定浓度以后,能够诱导EcR与维甲酸X受体(retinoidXreceptor,RXR)形成有功能的EcR/RXR异源二聚体,进而启动蜕皮激素信号通路产生级联反应,诱导E75、E74、BroadComplex(BR-C)等早期应答基因的转录。这些早期应答基因进一步调控下游一些蛋白酶和其它基因的陆续表达,产生次级应答,从而调控节肢动物生长发育、细胞调亡、繁殖等生理过程。 本文以我国东南沿海重要的海洋经济蟹类—拟穴青蟹(Sc...Ecdysone plays important roles in molting, regeneration and reproduction of the arthropod. Ecdysone receptor (EcR) is critical in the ecdysone signaling pathway. When ecdysteroid exceed the threshold, EcR is induced to assemble with retinoid X receptor (RXR), forming a functional EcR/RXR heterodimer receptor, which activates ecdysone signaling pathway and triggers the expressions of early ecdysone...学位:理学博士院系专业:海洋与地球学院_海洋生物学学号:2232012015345