多环芳烃(Polycyclicaromatichydrocarbons，PAHs)是一类广泛分布于环境中的持久性有机污染物(persistentorganicpollutants，POPs)。众多研究表明，PAHs不仅具有较强的致癌、致畸和致突变性，还具有胚胎发育毒性，尤其是心脏发育毒性。但到目前为止，PAHs心脏毒性的研究多集中于高浓度的急性暴露，而对环境浓度的PAHs暴露是否会同样的引发心脏发育毒性，研究还甚少；且关于低环数的PAHs的心脏发育毒性机制研究尚不清楚。本研究分别选取3环的菲（phenanthrene，Phe）和4环的芘（pyrene，Pyr），在环境水平（0，0.05，5，5...Polycyclic aromatic hydrocarbons (PAHs) are a kind of the most abundant and ubiquitous persistent organic pollutants (POPs) in environment. It is widely accepted that PAHs not only have carcinogenic, teratogenic, and mutagenic toxicity, but also developmental toxicity, especially the cardiotoxic effects. However, most of the studies concerning PAHs focus on high dose exposure, and the effects of e...学位：理学博士院系专业：生命科学学院生物学系_动物学学号：2162010015387
