人类出生缺陷已经成为当今世界各国最为重视的卫生问题。多环芳烃(Polycyclicaromatichydrocarbons,PAHs)是一类广泛分布于环境中的持久性有机污染物(persistentorganicpollutants,POPs),具有胚胎发育毒性,与人类出生缺陷密切相关。 目前为止,关于PAHs心脏毒性的研究大多集中于高浓度急性暴露毒性,而对于环境浓度下的PAHs暴露是否能引起同样的心脏发育毒性,研究甚少;同时,低环数的PAHs,例如Phe的心脏发育毒性机制的研究尚不明朗;并且,关于胚胎时期短暂的低浓度PAHs暴露对成年后心脏功能的影响的相关研究还很少。 流行病学研究的数据表...Human birth defects have been a major issue in the world. Polycyclic aromatic hydrocarbons (PAHs) are a kind of the most abundant and ubiquitous persistent organic pollutants (POPs) in the environment. PAHs have developmental toxicity, which is closely related to human birth defects. However, most of the studies concerning PAHs focus on high dose exposure, and the effects of environmental relevant...学位:理学博士院系专业:生命科学学院_细胞生物学专业学号:2162011015393