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Structural study of NS1 protein from an influenza Avirus

Abstract

A型流感病毒(influenzaAvirus)属于正粘病毒科,为单股负链RNA病毒,其基因组由8个节段组成,编码11种蛋白质。它能引起急性呼吸道传染病,具有传染性强,发病率高,容易引起流行或大流行等特点。A型流感病毒是重要的人畜共患病病原,人畜共患的特征使其有产生大流行的潜力。20世纪至今先后爆发了多次全球性大流感,对人类的生命健康和社会生活形成了巨大的威胁。NS1(non-structuralprotein1)是A型流感病毒的非结构蛋白,是一种多功能调节蛋白,在调节流感病毒的致病性及毒力方面发挥着重要作用。NS1蛋白从病毒和宿主两个方面来调节病毒的致病性和毒力。在病毒方面,NS1蛋白可以通过...Influenza A virus belongs to the Orthomyxoviridae family. It contains a single-strand,negative sense, segmented RNA genome consisting of eight segments of viral RNA,which encode 11 known proteins. It can cause an acute respiratory infectious disease,which is characterized by strong infectivity, high incidence and easily lead to the outbreak or pandemic. Influenza A virus is important pathogen with...学位:理学硕士院系专业:生命科学学院生物学系_生物化学与分子生物学学号:2172009115205

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