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Study on the Effects and Mechanisms of Recombinant Human Prothymosin α of antitumor activity

Abstract

胸腺素α原(Prothymosinα,ProTα)是胸腺素α1(Tα1)的前体蛋白,在哺乳动物细胞中广泛分布,在淋巴组织及非淋巴组织均可找到。在细胞内,ProTα作为一种核蛋白,参与对细胞周期的调节,促进细胞增殖;在细胞外,胸腺素α原通过潜在的膜受体调节免疫应答,促进IFN-γ、TNF-α、IL-2等细胞因子的产生,进而增强细胞和体液免疫应答。 胸腺素α原作为一种免疫调节因子,对抑制肿瘤生长有一定效果。本实验主要研究胸腺素α原分别联合白介素-2和γ-干扰素,对荷瘤小鼠的肿瘤抑制效果,实验结果证明胸腺素α原联合白介素-2的抑瘤效果优于单独使用。对肿瘤组织进行H&E染色,观察肿瘤细胞,可看出被抑...Prothymosin alpha (ProTα) is the precursor protein of thymosinα1(Tα1), it is a small molecule of natively unstructured acid protein. it widely exists in mammalian tissues. It could be found in lymphoid tissue as well as in non-lymphoid tissues. in the exterior of cell, Prothymosin alpha, as a nucleoprotein, participate in the regulation of cell cycle, promote Cell Proliferation; But in extra cellu...学位:理学硕士院系专业:生命科学学院生物学系_生物化学与分子生物学学号:2172008115261

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