β-淀粉样前体蛋白APP（β-amyloidprecursorprotein）水解产生的β-淀粉样蛋白（β-amyloidpeptides，Aβ）在阿尔茨海默氏症（AlzheimerDisease，AD）的发病机理中起着重要的作用，BACE（β-siteAPP-cleavingenzyme）被认为是Aβ形成的关键酶，已经成为近年来阿尔茨海默氏症研究及筛选药物靶的热点之一。为了更好的认识和理解BACE在阿尔茨海默氏症病理过程中的作用机制，我们利用酵母双杂交法筛选与之有相互作用的蛋白。用BACE作为诱饵蛋白筛选人胎脑文库后，得到65个阳性克隆。经测序和序列比对，我们选择三个蛋白进行深入研究：分别为...The β-amyloid peptides (Aβ) derived from proteolytic cleavage of the amyloid precursor protein (APP) play a major role in the pathogenesis of Alzheimer’s disease (AD) by forming aggregated, fibrillary complexes that have been shown to be neurotoxic. The β-site APP cleaving enzyme (BACE) has been identified as a key enzyme leading to β-amyloid formation. To further understand the function a...学位：理学硕士院系专业：生命科学学院生物医学科学系_细胞生物学学号：20032608
