在真核细胞中，编码蛋白基因的转录均由RNA聚合酶II(RNAPolII)来完成，其转录表达调控是通过一系列复杂而精致的机制而完成的。过去，人们均认为基因转录前起始复合物（Pre-initiationComplex，PIC）的组装和转录起始（Initiation）是调控基因转录表达，应对细胞内外信号的唯一调控平台。但近年来，越来越多的证据表明，在诸如细胞生长、细胞分化和应对环境变化等多种过程中，基因转录的延伸阶段在调控基因表达过程中也扮演了极其重要的角色。P-TEFb复合体是由Cdk9及CyclinT1组成的异二聚体激酶，在转录延伸过程中可磷酸化RNAPolII大亚基CTD上第2位丝氨酸、负性转...In eukaryotes, the transcription of protein coding genes by RNA polymerase II is under intricate regulation. Traditionally, the assembly of Pre-initiation complex (PIC) and transcriptional initiation were regarded as the key steps for transcriptional regulation in response to external signals. Recently, however, accumulating evidence indicated that the regulation of transcriptional elongation also...学位：理学博士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：2172008015041
