Wnt信号通路控制多种细胞的命运，参与细胞的增殖、分化、凋亡等基本过程，在正常组织发育以及肿瘤形成中都起着非常重要的作用。经典Wnt信号转导通路，通过关键因子β-catenin（果蝇中为Armadillo）对靶基因转录进行调控。WNT信号存在的情况下，β-catenin进入核内，与TCF结合，并募集许多转录激活相关因子，从而激活靶基因转录。pygopus通过PHD与Lgs/BCL9直接结合，并由此与β-catenin的N端间接结合。目前已经证实β-catenin与某些组蛋白甲基化转移酶（HMT）复合体成员有关，并且这种相互作用是β-catenin参与Wnt靶基因转录激活的关键机制。染色体重组相...Wnt signalling pathway plays a signifficant role in determining cell fate and cell growth, differentiation, apoptosis, which is also very important during the normal tissue development or tumorigenesis. In canonical Wnt pathway, the key effector is β-catenin, which is transported into nucleus and binds with TCF, recruiting many transcription factor and finally regulating the target gene expressio...学位：理学硕士院系专业：生命科学学院生物学系_细胞生物学学号：2172006115219
