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Screening,isolation and identification of fungal anti-tumor components from deep-sea sediments and primary research on anti-tumor mechanism of F1120

Abstract

随着工业污染和环境破坏的日益严重,恶性肿瘤发病率正在逐年提高,而常 规抗癌药物又具有很大的副作用,所以抗肿瘤药物的研发以及新颖的抗肿瘤药物 作用靶点的研究已经成为生命科学领域研究的重要课题。众所周知,深海具有高 压,低温,寡营养的特点,为了适应生存环境,生活在其中的微生物往往产生了 形成复杂多样的代谢途径,所以深海微生物资源为筛选新颖的抗肿瘤化合物提供 了丰富的来源。其中,深海真菌不仅具备了深海微生物的特殊性,又具有真菌本 身复杂的代谢途径,加之对于深海来源的抗肿瘤化合物的研究比较少,所以对于 深海真菌来源的抗肿瘤化合物的研究具有很好的前景。 本课题从大洋第十九航次采集的深海沉...Along with industrial pollution and the growing environmental damage, the incidence of malignant tumor is gradually increased year by year, while the conventional antitumor drugs also have significant side effects. As the result, the development of antitumor drugs and the detecting of novel targets for antitumor drug have become the vital research projects in life science area. As we know, dee...学位:理学硕士院系专业:生命科学学院生物学系_生物化学与分子生物学学号:2162007115192

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