三叶因子家族（Trefoilfactorfamily,TFF）是一群分子量为12-22KD、主要表达于粘膜上皮、发挥增强上皮细胞防御及促进粘膜修复重建的小分子多肽，这种作用有别于其他具有粘膜保护功能的小分子多肽，证明三叶三叶因子家族在粘膜保护中发挥独特作用。在胃肠道中，三叶因子1大量表达于包括胃小凹在内胃粘膜上皮细胞，在十二指肠布氏腺体低表达。在基因敲除TFF1小鼠模型胃粘膜癌变及在近50%人类胃癌中下调表达证明TFF1可能是胃癌抑癌基因。在炎症及胃肠道损伤情况下TFF1与三叶因子家族其他成员经自分泌或旁分泌的形式上调表达，通过诱发上皮细胞迁移及避免迁移过程中失巢凋亡维持上皮细胞连续性。除了上...The trefoil factor family (TFF) comprises a group of small (12 – 22 kD) peptides, seem crucial for epithelial protection and restitution, especially on mucosal surfaces, and they utilize pathways different from the conventional peptides engaged in restitution, suggesting a unique role of the TFFs in this process.In the GI tract, TFF1 is highly expressed in gastric surface epithelial cells includin...学位：理学博士院系专业：医学院_生理学学号：2452009015373
