Interaction and structure of a host-guest inclusion complex of symmetrical tetramethyl substituted cucurbit[6]uril (TMeQ[6]) with 2-(aminomethyl)pyridine (amp) have been studied by using H-1 NMR technique, UV-visible spectrophotometry and single crystal X-ray diffraction determination. The experimental results from H-1 NMR and UV-visible spectra revealed that the amp as a guest enters into the cavity of TMeQ[6] to form a host-guest inclusion complex of TMeQ[6] and amp with a constant ratio of 1:1. The single crystal X-ray diffraction determination further confirmed the conclusions
