Babic, Ilijana

Huang, Xu-Feng

Osborne, Ashleigh L

Solowij, Nadia

Weston-Green, Katrina

English

Research Online

University of Wollongong Research Online Faculty of Science, Medicine and Health - Papers: part A Faculty of Science, Medicine and Health 1-1-2016 Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophrenia Ashleigh L. Osborne University of Wollongong, alo649@uowmail.edu.au Nadia Solowij University of Wollongong, nadia@uow.edu.au Ilijana Babic University of Wollongong, ib171@uowmail.edu.au Xu-Feng Huang University of Wollongong, xhuang@uow.edu.au Katrina Weston-Green University of Wollongong, kweston@uow.edu.au Follow this and additional works at: https://ro.uow.edu.au/smhpapers  Part of the Medicine and Health Sciences Commons, and the Social and Behavioral Sciences Commons Recommended Citation Osborne, Ashleigh L.; Solowij, Nadia; Babic, Ilijana; Huang, Xu-Feng; and Weston-Green, Katrina, "Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophrenia" (2016). Faculty of Science, Medicine and Health - Papers: part A. 4114. https://ro.uow.edu.au/smhpapers/4114 Research Online is the open access institutional repository for the University of Wollongong. For further information contact the UOW Library: research-pubs@uow.edu.au Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophrenia Abstract Abstract of a poster presentation. Disciplines Medicine and Health Sciences | Social and Behavioral Sciences Publication Details Osborne, A. L., Solowij, N., Babic, I., Huang, X. & Weston-Green, K. (2016). Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophrenia. International Journal of Neuropsychopharmacology, 19 (Suppl. 1), 183-183. This journal article is available at Research Online: https://ro.uow.edu.au/smhpapers/4114 Abstracts | 183SFN-rich broccoli sprouts in subjects at a high-risk of developing psychosis may prevent the onset of psychosis at adulthood.PM366Three-dimensional analysis of morphological changes in dendritic spines and mitochondria in dentate gyrus granule cells in Schnurri-2 knockout mice, an animal model for schizophreniaAkito Nakao,Fujita Health University, JapanAbstractAccumulating evidence suggests that morphological changes of subcellular-scale structures such as dendritic spine and mito-chondria may be involved in the pathogenesis/pathophysiology of schizophrenia. Previously, we have proposed mice lacking Schnurri-2 (Shn2), an MHC enhancer binding protein, as a schizo-phrenia model with mild chronic inflammation. In the mutants, there are decreases in the expression level of PSD95, synaptic marker, and increases in C1q family genes (C1qa, C1qc and C1ql2), which are considered to mediate synapse elimination during the postnatal development. In the present study, we analyzed three-dimensional morphological changes in dendritic spines and mito-chondria in dentate gyrus granule cells in Shn2 KO mice by serial block-face scanning electron microscopy. The mutants showed about 13% increase in spine length, and about 25% increase in spine neck length. There were no significant differences between Shn2 KO and wild-type mice in their spine density, volume of spine, spine head length, or spine head diameter. The mutants exhibited reduced complexity in mitochondrial morphology, sug-gesting that a balance between mitochondrial fusion and fission is compromised in Shn2 KO mice. These morphological changes in spines and mitochondria may be associated with functional impairments of those subcellular-scale structures, and represent potential endophenotype of schizophrenia.PM367Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophreniaAshleigh L. Osborne1, 2, Nadia Solowij3, 4, Ilijana Babic1, 2, Xu-Feng Huang1, 2, Katrina Weston-Green1, 21 School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, 2522, NSW, Australia 2 Centre for Translational Neuroscience, Illawarra Health and Medical Research Institute, University of Wollongong, 2522, NSW, Australia 3 School of Psychology, Faculty of Social Sciences, University of Wollongong, 2522, NSW, Australia 4 Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, 2522, NSW, AustraliaAbstractBackground: Maternal immune activation (MIA) during preg-nancy is a risk factor for schizophrenia and may be linked to cognitive deficits of the disorder [1,  2]. Current antipsychotics show minimal improvement of cognitive deficits [3] and have adverse side-effects [4]. Cannabidiol (CBD), a constituent of can-nabis, possesses anti-inflammatory, antipsychotic and neuro-protective properties [5]; however, whether CBD can improve cognition in schizophrenia is unknown. The aim of this study was to examine effects of CBD on cognition in a MIA model of schizophrenia.Methods: Pregnant dams were administered either poly IC (POLY; 4mg/kg) or saline (CONT). From postnatal day 56, offspring were administered either vehicle (CONT+VEH, POLY+VEH) or CBD (10 mg/kg; CONT+CBD, POLY+CBD) twice daily for 3 weeks (n=12 males, 12 females/group). Novel object recognition (NOR) and T-maze tests were performed to assess recognition and working memory.Results: In the NOR test, POLY+VEH males spent significantly less time exploring the novel object compared to CONT+VEH counterparts (p<0.01), and in the T-maze test, POLY+VEH males exhibited a lower number of correct entries (p<0.01 vs. CONT+VEH). Performance of POLY+CBD males was significantly better than POLY+VEH in both tests (p<0.05) and did not differ from CONT+VEH (p>0.05). No differences were observed between CONT+VEH and CONT+CBD males (p>0.05). There was no effect of poly IC or CBD treatment on female offspring performance in either test (p>0.05).Conclusions: Interestingly, CBD treatment restored working and recognition memory impairments in the poly IC model of schizophrenia, but had no effect in control rats. These effects were observed in male offspring, whereas females showed no cognitive impairment. The mechanisms underlying the appar-ent protection in females and sensitivity in males warrant fur-ther investigation. This is the first study to examine chronic CBD treatment effects in a MIA model, and suggests that CBD may have sex-specific therapeutic potential for schizophrenia-related cognitive impairments.References1. Brown AS, Patterson PH (2011) Maternal infection and schizo-phrenia: Implications for prevention. Schizophrenia Bulletin 37(2):284–90.2. Brown AS, Vinogradov S, Kremen WS, Poole JH, Deicken RF, Penner JD, McKeague IW, Kochetkova A, Kern D, Schaefer CA (2009) Prenatal exposure to maternal infection and executive dysfunction in adult schizophrenia. The American Journal of Psychiatry 166(6):683–690.3. Barch DM, Ceaser A (2012) Cognition in schizophrenia: Core psychological and neural mechanisms. Trends in Cognitive Sciences 16(1):27–34.4. Weston-Green K, Huang X-F, Deng C (2013) Second Genera-tion Antipsychotic-Induced Type 2 Diabetes: A  Role for the Muscarinic M3 Receptor. CNS Drugs 27(12):1069–80.5. Schubart CD, Sommer IEC, Fusar-Poli P, de Witte L, Kahn RS, Boks MPM (2014) Cannabidiol as a potential treatment for psychosis. European Neuropsychopharmacology 24(1):51–64.PM368Ketogenic diet normalises schizophrenia-like behaviours in acute and chronic NMDA-receptor hypofunction modelsAnn-Katrin Kraeuter1, Heather Loxton1, Bruna Costa Lima1, Donna Rudd2, Maarten van den Buuse3 and Zoltán Sarnyai1*1Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine and College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, 4811 QLD, Australia 2Biomedicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, 4811 QLD, Australia 3School of Psychology and Public Health, La Trobe University, Bundoora, Melbourne VIC 3086, Australia *Presenting senior authorsAbstractObjective: Impaired glucose and energy metabolism may play a role in the pathobiology of schizophrenia. Abnormal brain energy metabolism has been found in animal models of 

Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophrenia

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Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophrenia

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