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Borrelia burgdorferi specific serum and cerebrospinal fluid antibodies in Lyme neuroborreliosis
Authors
Otto Glader
Jukka Hytönen
+4 more
Mari Kanerva
Elisa Kortela
Jarmo Oksi
Annukka Pietikäinen
Publication date
1 November 2022
Publisher
Doi
Cite
Abstract
Publisher Copyright: © 2022 The Author(s)We used definite Lyme neuroborreliosis (LNB) adult patient acute and convalescent phase serum (n = 63 and 61, respectively) and cerebrospinal fluid (CSF; acute n = 63, 3 weeks timepoint n = 41) samples to characterize Borrelia burgdorferi specific antibody responses in patient subgroups categorized by demographics, infection manifestation and phase, infecting B. burgdorferi genospecies, received antibiotic treatments, and treatment outcome. B. burgdorferi antibodies were analyzed using 4 different assays incorporating a large array of antigens. We observed that B. burgdorferi specific serum antibodies show a universal, antigen independent declining trend after antibiotic treatment of LNB at 1 year. Antibodies declined similarly among women and men over time, and the decline was independent of patient age. The antibody responses were independent of the predominant LNB manifestation, treatment received by the patient, infecting B. burgdorferi genospecies, or the subjective improvement experienced by the patients. Finally, the antibody specificities in CSF reflected the specificities observed in serum samples.Peer reviewe
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Last time updated on 06/10/2022