Large size data requires more storage space, communication time, communication bandwidth and degrades host image
quality when it is embedded into it as watermark. Lossless compression reduces data size better than lossless one but with permanent loss of important part of data. Data lossless compression reduces data size contrast to lossy one without any data loss. Medical image data is very sensitive and needs lossless compression otherwise it will result in erroneous input for the health recovery process. This paper focuses on Ultrasound medical image region of interest(ROI) lossless compression as watermark using different techniques; PNG, GIF, JPG, JPEG2000 and Lempel Ziv Welsh (LZW). LZW technique was found 86% better than other tabulated techniques. Compression ratio and more bytes reduction were the parameters considered for the selection of better compression technique. In this work LZW has been used successfully for watermark lossless compression to watermark medical images in teleradiology to ensure less payload encapsulation into images to preserve
their perceptual and diagnostic qualities unchanged. On the other side in teleradiology the extracted lossless decompressed watermarks ensure the images authentication and their lossless recoveries in case of any tamper occurrences
