Trueperella pyogenes is an opportunistic bacterial pathogen causing several infectious diseases, including metritis,
mastitis and abscesses in domestic animals such as dairy cattle. Several virulence proteins are released by
T. pyogenes strains contributing to the pathogenic and causing disease potential of this pathogen. So far, many
aspects of T. pyogenes pathogenesis are unknown. In this study, expression levels of plo, fimA, nanH and cbpA
genes encoding pyolysin, fimbriae, neuraminidase and collagen-binding protein, respectively in T. pyogenes
isolated from totally 15 metritis, mastitis and cutaneous abscesses convenience samples in response to co-culture
with other pathogens including E. coli, St. dysgalactiae, S. aureus, F. necrophorum and L. plantarum strains in mice
study model have been investigated. We found that expression levels of plo, fimA, nanH and cbpA genes in
T. pyogenes isolates in response to co-culture with F. necrophorum and E. coli were significantly increased;
however, no significant changes was seen in the level of expression of these genes in the isolates in response to
co-culture with St. dysgalactiae and S. aureus. Notably, expression of all virulence factor genes was suppressed in
T. pyogenes in response to co-culture with L. plantarum. We observed that L. plantarum might be used to prevent
infectious diseases caused by T. pyogenes