Microplastic pollution is contaminating the human food chain worldwide. At the same time, construction excessively exploits natural sand, requiring the incorporation of alternative materials to achieve sustainable development. From this scenario, the study evaluates the potential of recycled micro-PET replacing natural sand on hot-mix asphalt (HMA) mechanical behavior by weight and volume. The materials’ characterization occurred via XDR, XRF, TGA/DTG, FTIR, SEM, and AFM tests. The Superpave mix design, X-ray micro-tomography (μ-CT), indirect tensile strength (ITS), resilient modulus (RM), and moisture damage tests were performed in conventional and PET-incorporated mixtures, considering 2% (in wt.), 4% (in wt.), and 8% (in wt. and vol.) substitutions. The 8% PET replacing sand by volume showed no significant change in the mixture’s optimum asphalt
content (OAC) due to the binder absorption equivalence between the materials’ surfaces. For the same binder
content, the increase in PET content in weight decreased the binder film thickness and increased the volume of
voids, visualized as non-permeable micropores in μ-CT. Although adding and incrementing PET reduced the
mixtures’ ITS and RM values, its most significant contribution was enhancing the resistance to moisture damage,
especially for regions where the pavement deterioration process is associated with an intensive rainfall regime,
thus demonstrating this application’s practical feasibility in concrete asphalt paving
