Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disease and characterized by extreme clinical and genetic heterogeneity. Information on the prognostic value of genotype is currently limited. In this thesis, we compared the clinical phenotype and outcome of genotype-positive and genotype-negative patients with HCM during long-term follow-up; genotype-positive status was an independent risk factor of mortality. In addition, we analyzed the clinical findings and outcome in patients with Dutch Myosin-Binding Protein C founder mutations and found no difference in compariso
