The development of left ventricular hypertrophy in subjects with

      hypertrophic cardiomyopathy (HCM) is variable, suggesting a ro

Cate, F.J. (Folkert) ten

Danser, A.H.J. (Jan)

Deinum, J. (Jacob)

Gool, J.M. (Jeanette) van

Kofflard, M.J.M. (Marcel)

The development of left ventricular hypertrophy in subjects with

      hypertrophic cardiomyopathy (HCM) is variable, suggesting a role for

      modifying factors such as angiotensin II. Angiotensin II mediates both

      trophic and antitrophic effects, via angiotensin II type 1 (AT(1)-R) and

      angiotensin II type 2 (AT(2)-R) receptors, respectively. Here we

      investigated the effect of the AT(2)-R gene A/C(3123) polymorphism,

      located in the 3' untranslated region of exon 3, on left ventricular mass

      index (LVMI) in 103 genetically independent subjects with HCM (age, 12 to

      81 years). LVMI and interventricular septum thickness were determined by

      2D echocardiography. Extent of hypertrophy was quantified by a point score

      (Wigle score). Plasma prorenin, renin, and ACE were determined by

      immunoradiometric or fluorometric assays, and genotyping was performed by

      polymerase chain reaction. In men, no associations between AT(2)-R

      genotype and any of the measured parameters were observed, whereas in

      women, LVMI decreased with the number of C alleles (211+/-19, 201+/-18,

      and 152+/-10 g/m(2) in women with the AA, AC, and CC genotype,

      respectively; P=0.015). Similar C allele-related decreases in women were

      observed for interventricular septum thickness (P=0.13), Wigle score

      (P=0.05), plasma renin (P=0.03), and plasma prorenin (P=0.26). Multiple

      regression analysis revealed that the AT(2)-R C allele-related effect on

      LVMI (beta=-30.7+/-11.1, P=0.010) occurred independently of plasma renin,

      the AT(1)-R gene A/C(1166) polymorphism, or the ACE gene I/D polymorphism.

      In conclusion, AT(2)-Rs modulate cardiac hypertrophy in women with HCM,

      independently of the circulating renin-angiotensin system. These data

      support the contention that AT(2)-Rs mediate antitrophic effects in

      humans

Erasmus University Digital Repository

Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy

http://repub.eur.nl/pub/9810/11751703.pdf

Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy

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