The objectives of this thesis were to provide more insight into the risk and risk factors of
adverse drug reactions associated with HIV-protease inhibitor treatment under non-experimental
everyday circumstances. By recognition of risk factors, patients at risk can be
identified beforehand and risk management can be targeted more efficiently, hence
ultimately improving the safety of HIV-protease inhibitor treatment. In the studies presented
in this thesis we applied multiple research strategies. tn which the nationwide ATHENA cohort
played a central role
