If indeed vagal withdrawal determines the rapid response to exercise (phase I), the a large reduction, if not complete suppression, of phase I should be found, when an exercise transient starts from a previous lower steady state exercise rather than from rest. On 15 healthy young subjects we measured beat-by-beat cardiac output (Q̇, Modelflow from Portapres data) and heart rate (fH, ECG) during these cycle ergometer exercise transients: 0–50 W (transient from rest, RT) and 50–100W (transient from exercise, ET). A double exponential was used to compute amplitudes and time constants of phase I and II (A1 and A2; T1 and T2). At steady state, fH was 87.510.4, 109.312.0, and 139.617.1bpm, and Q̇ was 7.31.5, 12.61.6, and 16,11,9L/min, at rest, 50W and 100W, respectively. In RT, A1 and A2 for fH were 11.78.6 and 11.34.7bpm; the corresponding T1 and T2 were 1.61.9 and 14.421.3s. For Q̇, we had: A1=4.01.8L/min, A2=1.51.4L/min, T1=3.21.8s, T2=11.312.2s. In ET, the double exponential model provided preposterous A1 and T1 values and extremely high T2 values (>100s). Subsequent use of a mono exponential model provided, for fH, A=29.78.9bpm and T=7.74.9s, and for Q̇, A=3.58.6L/min, and T=7.05.7s. The A and T in ET did not differ from the A2 and T2 of RT. We conclude that a single exponential model is more adequate to describe ET and this single exponential corresponds to the second exponential of RT. Our results are compatible with the vagal withdrawal hypothesis
