Schematic representation of possible mechanisms of host cell invasion by <i>T</i>. <i>cruzi</i> strains G and CL.

Abstract

Host cell invasion by G strain MT involves the interaction of gp35/50 mucins with annexin A2, FAK activation and F-actin recruitment, whereas CL strain MT internalization relies on the recognition of gp82 by LAMP2, activation of PKC and ERK1/2, disruption of F-actin and spreading of lysosomes to the cell periphery.</p