Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

Abstract

Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.National Institutes of Health (U.S.) (NIH-MLPCN program (1 U54 HG005032-1))National Institutes of Health (U.S.) (NIH (1 R03 MH086456-01)