202208 bcchNot applicableOthersNational Natural Science Foundation of China [81473082, 22077020 and 32050410289];Natural Science Foundation of Guangdong Province, China [2017A030313078, 2017A030313071, and 2019A1515011799];Health and Medical Research Fund (HMRF), Hong Kong SAR [19200231];PolyU Startup Fund [P0035712];PolyU SZRI fund [A0039278]Published24 month