Additional file 1 of Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis

Abstract

Additional file 1. Fig. S1. Erbin deficiency facilitates NLRP3 inflammasome activation and pyroptosis of microglia in vivo and vitro. Fig. S2. Erbin regulates pyroptosis via IRE1α/Xbp1s/Ca2+ in vivo and vitro. Fig. S3. Erbin inhibits pyroptosis via IRE1α/Xbp1s/Ca2+ in BV2 cells and improves synaptic proteins by inhibiting IRE1α/Xbp1s pathway. Fig. S4. LPS/nigericin stimulation resulted in decreased TXNIP protein levels regardless of Erbin knockdown in BV2 cells