Cytomegaloviruses undergo the classical morphologic stages of replication in hedgehog submandibular gland duct cells. A profound cytomegaly is associated with the infection. These features indicate that the hedgehog may be an excellent model in which to study the biology of cytomegalovirus-salivary gland interactions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66837/2/10.1177_00220345830620031501.pd