In this article, a neural integral sliding mode control strategy is presented for the finite-time fault-tolerant attitude tracking of rigid spacecraft subject to unknown inertia and disturbances. First, an integral sliding mode controller was developed by originally constructing a novel integral sliding mode surface to avoid the singularity problem. Then, the neural network (NN) was embedded into the integral sliding mode controller to compensate the lumped uncertainty and replace the robust switching term. In this way, the chattering phenomenon was significantly suppressed. Particularly, the mechanism of indirect neural approximation was introduced through inequality relaxation. Benefiting from this design, only a single learning parameter was required to be adjusted online, and the computation burden of the proposed controller was extremely reduced. The stability argument showed that the proposed controller could guarantee that the attitude and angular velocity tracking errors were regulated to the minor residual sets around zero in a finite time. It was noteworthy that the proposed controller was not only strongly robust against unknown inertia and disturbances, but also highly insensitive to actuator faults. Finally, the effectiveness and advantages of the proposed control strategy were validated using simulations and comparisons
