Safety of contrast agents is reported in the years after. Both the intracoronary use of
sonicated Renografin as well as intravenous use of commercial product as
Albunex and Lechovist has been investigated. Thereafter more pathophysiologic
studies were performed. Ten Cate described the possibilities to determine the
stenosis of the left anterior descending coronary artery by the contrast outwash in
the interventricular septum and Cornel who incidentally reported the Thebesian
vein outflow in humans visualised by echo contrast. Cheiriff and his group described
myocardial perfusion studies to determine coronary flow reserve before and after
Percutaneous Transluminal coronary angioplasty (PTCA). Coronary collateral
perfusion after myocardial infarction or PTCA can be assessed. Also, successful
thrombolysis, resulting in a patent coronary artery, is often not accompanied by a
return of normal perfusion or wall motionUltrasound contrast agents have been used in the medical diagnostic field for a
number of years and for very different purposes. These agents have been employed
when echo images proved inadequate or when further information about the blood
flow was required. Originally, contrast agents were home-made, being produced
simply by passing saline through a
