In recent years the value of the use of evaluation methods in all aspects of economic sectors, including the field of health care, has been increasingly recognized. The thrust of this paper is to explore the potential use of a) Cost-Benefit Analysis and b) Simulation and Modeling methods in estimating the value of Health Information System (HIS) projects. These methods were chosen for consideration as the most appropriate, primarily because CBA can measure delivered value of HIS interventions by weighting cost and benefits and identifying what is more socially desirable, while Simulation and Modeling tools can be used to estimate the future value of health care changes concerning HIS. The paper discusses these two families of methods, their evaluation potential is analyzed, and arguments for and against the use of each method are presented. Finally, methodological considerations and limitations are discussed and areas for future research are suggested
