Improving organizational performance is the main objective of any organization.Six Sigma is one of the most important approaches to improve performance and sustain competitive advantage. This article reviewed the literature related to organizational performance and explains the potential impact of Six Sigma and innovation culture on organizational performance. Given that previous studies have reported inconclusive results, this paper tries to establish a mechanism to explain the role of Six Sigma in improving organizational performance. Therefore, based on the theoretical foundation and comprehensive review of previous literature, a research framework is proposed. This proposed framework is grounded in the implementation of Six Sigma projects; it also establishes that innovation culture can help organizations to achieve success in a turbulent business environment