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Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis
Authors
Altman
Autexier
+108 more
Barrera
Beebe
Beebe
Brannvall
Brannvall
Brown
Brown
Buck
Buck
Busch
Chamberlain
Christian
Christian
Christian
Crary
Crary
Day-Storms
DeRose
Doudna
Evans
Fahlman
Fang
Frank
Frank
Gardiner
Getz
Gluick
Gondert
Gopalan
Gopalan
Gossringer
Guerrier-Takada
Guo
Haebel
Hall
Hanna
Hardt
Hardt
Harris
Harris
Hartmann
Henkels
Hsieh
Jovanovic
Kaye
Kazantsev
Kazantsev
Kikovska
Kirsebom
Kole
Komine
Krasilnikov
Krasilnikov
Kurz
Kurz
LaRiviere
Li
Li
Loria
Loria
Loria
Loria
Loria
Loria
Lott
Massire
Meier
Niranjanakumari
Niranjanakumari
Niranjanakumari
Noller
Oh
Oh
Pan
Pan
Pannucci
Patel
Peck-Miller
Pomeranz Krummel
Record
Reich
Rox
Rueda
Schmitz
Smith
Spitzfaden
Staley
Stams
Sun
Sun
Talbot
Tallsjo
Terada
Torres-Larios
Torres-Larios
Trang
Tsai
Tsai
Walker
Waugh
Wegscheid
Westhof
Westhof
Willkomm
Wilson
Wilson
Zahler
Zahler
Publication date
1 January 2007
Publisher
'Wiley'
Doi
Cite
Abstract
Ribonuclease P (RNase P) is a ribonucleoprotein (RNP) complex that catalyzes the metal-dependent maturation of the 5′ end of precursor tRNAs (pre-tRNAs) in all organisms. RNase P is comprised of a catalytic RNA (P RNA), and at least one essential protein (P protein). Although P RNA is the catalytic subunit of the enzyme and is active in the absence of P protein under high salt concentrations in vitro, the protein is still required for enzyme activity in vivo. Therefore, the function of the P protein and how it interacts with both P RNA and pre-tRNA have been the focus of much ongoing research. RNA-protein interactions in RNase P serve a number of critical roles in the RNP including stabilizing the structure, and enhancing the affinity for substrates and metal ions. This review examines the role of RNA-protein interactions in bacterial RNase P from both structural and mechanistic perspectives. © 2007 Wiley Periodicals, Inc. Biopolymers 87: 329–338, 2007. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at
[email protected]
Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57327/1/20846_ftp.pd
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