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Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients
Authors
Alguacil
Begg
+47 more
Blanck
Blot
Chan
Dekov
Dergham
DiGiuseppe
Fryzek
Fujiwara
Ghadirian
Grunewald
Hartge
Howe
Hruban
Hruban
Ibrahim
Jemal
Jen
Jen
Kriegel
Lemoine
Li
Lohr
Nagata
Ojajarvi
Pernick
Porta
Porta
Porta
Rall
Reinhardt
Scarpa
Schroeder
Siegel
Soliman
Soliman
Soliman
Soliman
Soliman
Soliman
Song
Stanley
Stanley
van der Heijden
Weiderpass
Weyrer
Yamaguchi
Yamasawa
Publication date
1 January 2006
Publisher
'Wiley'
Doi
Cite
Abstract
Variations in genetic mutations in pancreatic carcinoma between different populations have not been studied extensively, especially in developing countries where pancreatic cancer is rare. We studied the molecular pathology of 44 pancreatic carcinomas from patients residing in a heavily polluted region in the Nile River delta and compared the findings with tumors from 44 United States (US) patients. We evaluated K-ras mutations in codon 12, p53 mutations in exons 5–8, and Gadd45a mutations in exons 1 and 4. Overall, rates of K-ras , p53 and Gadd45 mutations were not statistically different in tumors of patients from Egypt and the US (67.4 vs. 63.4%; 27.3 vs. 36.4% and 9.1 vs. 4.5%, respectively). However, there were distinct differences in the specific types of K-ras and p53 mutations between the 2 groups. In K-ras , G → T transversion mutation was more frequent in the tumors from Egypt than from the US (58.6 vs. 26.9%), whereas G → C transversion was detected in 26.9% of US tumors but none from Egypt ( p = 0.003). We also found a trend toward differences in the p53 exons in which mutations occurred, with higher frequency of exon 5 mutation and lower frequency of exon 6 mutation in Egyptian tumors. Logistic regression showed that K-ras G → T transversion mutations and p53 exon 6 mutations were predicted by the country of residence of the patients. Our study identifies that there are differences in the types of mutations found in tumors from pancreatic carcinoma patients in Egypt and the US, and suggests that environmental factors may explain these differences. © 2006 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/55779/1/21986_ftp.pd
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