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Cadherin-4 plays a role in the development of zebrafish cranial ganglia and lateral line system
Authors
S. G. Babb-Clendenon
Kate F. Barald
+6 more
Bei Liu
Qin Liu
James A. Marrs
Jason Rostedt
Yu-Chi Shen
Amy L. Wilson
Publication date
1 March 2007
Publisher
'Wiley'
Doi
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on
PubMed
Abstract
We previously reported that cadherin-4 (also called R-cadherin) was expressed by the majority of the developing zebrafish cranial and lateral line ganglia. Cadherin-4 (Cdh4) function in the formation of these structures in zebrafish was studied using morpholino antisense technology. Differentiation of the cranial and lateral line ganglia and lateral line nerve and neuromasts of the cdh4 morphants was analyzed using multiple neural markers. We found that a subset of the morphant cranial and lateral line ganglia were disorganized, smaller, with reduced staining, and/or with altered shape compared to control embryos. Increased cell death in the morphant ganglia likely contributed to these defects. Moreover, cdh4 morphants had shorter lateral line nerves and a reduced number of neuromasts, which was likely caused by disrupted migration of the lateral line primordia. These results indicate that Cdh4 plays a role in the normal formation of the zebrafish lateral line system and a subset of the cranial ganglia. Developmental Dynamics 236:893–902, 2007. © 2007 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/55963/1/21085_ftp.pd
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Last time updated on 25/05/2012