The purpose of study is to do a literary review about the nurses working condition in psychiatric care ward and different factors affecting the nurse wellbeing in those work setting which are known to be a nursing field with different challenges with mentally sick patients. In the background, concepts of wellbeing are introduced. It also aims on finding and dis- cussing on possible interventions to ensure the wellbeing of nurse. The research questions are (1) what are factors affecting nurse’s wellbeing in psychiatric care ward? (2) what is possible intervention necessary to ensure wellbeing of nurse in psychiatric ward? Authors have used the human-to-human relationship model by Travelbee as main nursing theory and the Value fulfillment theory a non-nursing theory as a supporting theory as theoretical framework. Literature review is conducted in this study with 17 Articles using qualitative content analysis through inductive approach. Inclusion and exclusion criteria have been used where articles within 10 years from 2011 to 2021 with complete articles and free articles were included which were providing the normal situation of the population not focusing on any particular group of people. Sources of the articles used were PubMed, Science Direct and EBSCO. The findings from the literature review provides many factors affecting the wellbeing of nurses working in psychiatric care ward with many insights with evidence and suggestions for enhancement of nurses. The conclusion of study emphasizes primarily on establishing the good therapeutic relationship among patient and nurse empowering nurses with their personal skills with support of organizational improvements and the de-escalation of violence as second priority which emphasize on good arrangement of security and safe working environment providing well maintained and equipped facilities. The research had own limitations bounded by short time frame and reliance on literatures by other writers in the field, yet it sheds some light on the subject