Anthuber, Matthias

Claus, R.

Dintner, S.

Filippini, G.

Hackanson, B.

Kahl, Klaus-Henning

Kröncke, Thomas

Messmann, Helmut

Murnauer, M.

Märkl, B.

Schenkirsch, G.

Schmid, Christoph

Stüben, Georg

Trepel, Martin

Vollmer, C.

Märkl, Bruno

Claus, Rainer

OPUS Augsburg

                                               288P892Predicting outcome of oligometastatic colorectal cancer patients receiving local therapy for liver metastases Filippini G.1; Murnauer M.2; Vollmer C.3; Kahl H.4; Dintner S.5; Anthuber M.2; Kröncke T.6; Messmann H.3; Stüben G.4; Märkl B.5; Schenkirsch G.7; Trepel M.1; Schmid C.1; Claus R.1; Hackanson B.11ICCA, Klinikum Augsburg, Hämatologie, Onkologie und Stammzelltransplantation, Augsburg, Germany, 2ICCA, Klinikum Augsburg, Allgemein-, Viszeral- und Transplantationschirurgie, Augsburg, Germany, 3ICCA, Klinikum Augsburg, Gastroenterologie, Augsburg, Germany, 4ICCA, Klinikum Augsburg, Strahlenklinik, Augsburg, Germany, 5ICCA, Klinikum Augsburg, Pathologie, Augsburg, Germany, 6ICCA, Klinikum Augsburg, Radiologie, Augsburg, Germany, 7ICCA, Klinikum Augsburg, ICCA, Augsburg, GermanyIntroduction: Local therapy of liver metastases from colorectal cancer (CRC) in limited metastatic disease significantly improves survival and is considered a curative approach. Oligometastatic disease is an emerg-ing concept describing the transitional state between localized and wide-spread systemic disease. To better understand the clinical course of oligo-metastatic patients and predict, which patients could benefit from local ablative therapy, clinical tools such as prognostic scores are warranted.Methods: Here, we present outcome results of a retrospective analysis of 111 consecutive CRC patients who received local ablative therapy of liver metastases at our center between 2007 and 2016 and applied a prognostic score, which stratifies according to inflammatory response to tumor (IRT) before liver surgery. Results: Median age was 65 years (range (r): 28-89), median number of metastases was 2 (r: 1-7) and median follow-up from intervention to time of death/last contact was 21 months (r: 0-126). 93 (83.8%) patients were treated with liver resection; 8 (7.2%) patients received combined therapy with resection and thermal ablation; stereotactic body radiotherapy was used in 8 (7.2%) patients and 2 (1.8%) patients were treated with thermal ablation. Patients were stratified according to their preoperative IRT sta-tus: 25 (22,5%) patients were IRT positive (c-reactive protein (CRP) levels > 1.0 mg/dl), 86 (77,5%) patients were IRT negative (CRP levels ≤ 1.0 mg/dl). Median overall survival from time of local therapy was 20 months (r: 13,9-26 months) for IRT positive patients as compared to 71 months (r: 48,5-93,4) for IRT negative patients (p < 0,0001; hazard ratio (HR) 4,5; 95% CI 2,1-9,5). IRT status was not significantly associated with disease free survival (DFS) with median DFS of 9 months (r: 6,4-17,5) for IRT positive patients and 12 months (r: 0-18,2) for IRT negative patients (p =0,133; HR: 2,1; 95% CI 0,8-5,3).Conclusion: Beyond validating previous reports of IRT as a strong neg-ative prognostic factor we hypothesize that disease biology including ge-netic aberrations has a major impact on the clinical course and metastasis behavior. Therefore, in current analyses and in addition to phenotypical factors, we investigate molecular settings that may be associated with oli-gometastatic disease. Ultimately, we aim at developing an improved com-posite prognostic score to identify those patients who especially benefit from local therapy in oligometastatic CRC. Disclosure: No conflict of interest disclosed.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               

English

P892: Predicting outcome of oligometastatic colorectal cancer patients receiving local therapy for liver metastases [Abstract]

Predicting outcome of oligometastatic colorectal cancer patients receiving local therapy for liver metastases

Predicting outcome of oligometastatic colorectal cancer patients receiving local therapy for liver metastases

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